This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

It was at Frankfurt/Mainin 1899 that Paul Ehrlich first expounded his famous "site-chain theory" -which described the basic immunological principal of antibody-antigen interactio- on the occasion of the opening of the Institute for Experimental Therapeutics (which was later named after him). Nearly 100 years have passed since, and in retrospect it can be said that the "Ehrlich Era" (first steps in immunology "Magic Bullet" concept) and the "Behring Era" (detection of antibodies and serum therapy) formed the essential basis in the development of immunology. Niels K. Jerne, the former director of the Paul Ehrlich Institute in Frankfurt/Main received, together with Georges Kohler and Cesar Milstein, the Nobel Prize in Medicine 1984. These late successors of Ehrlich and Behring first described the hybridoma technology (in 1975) which enabled one of the most important and revolutionary technological innovations in the field of immunology -the production of monoclonal antibodies. It happens that, the time of the publication of this book, just a decade has passed since the first use of radiolabelled monoclonal antibodies in man (by the Lausanne Group). Over these 10 years a tremendous progress has taken place in the field of immunoscintigraphy: A large panel of highly specific monoclonal antibodies against tumour-associated antigens as well as normal cell compounds have been developed. Enormous progress has been made in the field of radiolabelling -from iodine-131 to technetium-99mor even positron-emittingradionuclides, e. g. iodine-124.

This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

Dieses Buch informiert }ber die Anwendung von Tumormarkern, Immunhistochemieund Immunszintigraphie bei gyn{kologischen Tumoren. Dabei werden die einzelnen Verfahren kritisch gewertet und Empfehlungen f}r die praktische Karzinomnachsorge gegeben. Der Leser erh{lt so eine Entscheidungshilfe, welche Parameter bei welchen Tumoren sinnvoll eingesetzt werden.

1. Advances in cancer imaging and therapy with radiolabelled antibodies.- 2. Evaluation of the diagnostic utility of immunoscintigraphy in oncology.- 3. The quality control and clinical testing of radiolabelled antibodies.- 4. Clinical utility of radiolabelled monoclonal antibodies in the management of gastrointestinal cancer.- 5. Use of 123-I radiolabelled F(AB')2 fragments of anti-CEA monoclonal antibody for the detection of primary and metastatic gastrointestinal carcinomas.- 6. Bispecific monoclonal antibodies for two phase radioimmunotherapy.- 7. Antimyosin antibody imaging in myocardial infarction.- 8. Antimyosin based radioimmunodetection of myocarditis cardiomyopathy and cardiac transplant rejection.- 9. Recent advances in the use of radiolabelled monoclonal antibodies in the management of ovarian cancer.- 10. Monoclonal antibodies for cell labelling with particular reference to thrombus imaging.- 11. The role of nuclear medicine in the evaluation of the patient with acquired immune deficiency syndrome (AIDS).- 12. Detection of inflammation/infection using radiolabelled anti-granulocyte antibodies: possibilities and limitations.- 13. A new marker for the detection of adenocardinomas by radioimmunoscintigraphy.- 14. New developments in the diagnosis of AIDS and strategies for therapy.

This handbook will provide updated information on nuclear medicine and molecular imaging techniques as well as its clinical applications, including radionuclide therapy, to trainees and practitioners of nuclear medicine, radiology and general medicine.

Updated information on nuclear medicine and molecular imaging are vitally important and useful to both trainees and existing practitioners. Imaging techniques and agents are advancing and changing so rapidly that concise and pertinent information are absolutely necessary and helpful.

It is hoped that this handbook will help readers be better equipped for the utilization of new imaging methods and treatments using radiopharmaceuticals.